Why Males And Females Reply In a different way To Hashish


By Lydia Kariuki

Historically, males have consumed hashish greater than females. Nonetheless, this hole is rapidly closing as extra females have gotten common hashish customers searching for each medical and leisure features. Do women and men expertise hashish in the identical method?

Key Takeaways

  • Men and women expertise hashish in a different way
  • Males have extra CB1 receptors within the CNS
  • Females have fewer however larger binding at CB1 receptors within the CNS
  • THC results are stronger and extended in females
  • Females might expertise larger ache and reduction from hashish in comparison with males
  • Hashish is more likely to cut back libido in males and improve it in females
  • Outcomes of sex-based variations in driving below the affect are conflicting.

How one experiences hashish is affected by a number of elements together with the chemovar in query, frequency of use, environmental setting, and even placebo results. On the physiological stage, two believable theories come to thoughts. One has to do with gonadal variations between women and men whereas the opposite has to do with the exceptional and intriguing endocannabinoid system.  And the 2 theories may nonetheless be interconnected.

It now emerges that women and men don’t have an equivalent endocannabinoid system and this makes them reply to hashish in a different way. In a nutshell, women and men can share a joint however find yourself having very completely different experiences.

Typically, hashish results which have been carefully linked to gender variations embrace anxiousness and melancholy, ache reduction, urge for food stimulation, sexual drive, power stability, and even the tendency to drive below the affect. The energy of the results and even negative effects skilled are apparently additionally influenced by male/ feminine variations within the ECS.

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On this article, we have now analyzed the outcomes from a assessment research investigating sex-based variations in responding to cannabinoids with a deal with cognitive and emotional habits. The assessment which was revealed in Behaviour Neuroscience in 2011 was titled “Sexually dimorphic results of cannabinoid compounds on emotion and cognition.” This text additionally mentions later research which have investigated the identical challenge.

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Cannabinoid Receptor Variations

From preliminary analysis, it seems that males have extra receptor binding websites for the CB1 receptors whereas the CB1 binding websites for females although minimal are extra environment friendly. Simply as a reminder, CB1 receptors are plentiful within the increased facilities and due to this fact are liable for many of the psychoactive results of hashish. These are the identical receptors to which anandamide (the bliss molecule) binds.

The research analyzed included younger rats, grownup animals, in addition to adolescents. Although a transparent image emerged from the evaluation the CB1 variance was stronger within the youthful rats.

Most research coated within the assessment centered on the hippocampus, amygdala, hypothalamus, and cortex. Males persistently confirmed a better prevalence of CB1 receptors in many of the cerebral areas. On the similar time, females confirmed increased CB1 receptor- G protein coupling.

In easier phrases, males seem to have extra CB1 receptors within the mind whereas females, even with fewer CB1 receptors, exhibit increased effectiveness on the CB1 receptor.

Intercourse Variations in Breakdown of THC

The assessment additionally examined intercourse variations within the breakdown of the psychoactive cannabinoid THC. In females, THC is metabolized to 11-OH-delta-9-THC which retains THC’s efficiency. In males, THC is metabolized to 11-OH-delta-9-THC and the opposite three metabolites, diminishing its efficiency. From this, the researchers concluded that since females have a better 11-OH-delta-9-THC, they’re more likely to expertise stronger and extended psychoactive results after consuming hashish.

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In a 2021 research, researchers used a rat mannequin to match the expression of the endocannabinoid system in women and men. The outcomes from this research revealed that certainly there are important sex-based variations within the expression of the ECS in elements of the central nervous system (CNS) which are concerned with power ache and anxiousness administration.

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A distinct research examined sex-based variations within the negative effects skilled by women and men after consuming hashish. Sometimes, females expertise extra negative effects from typical medicine. Contributors on this cross-sectional research have been adults with power non-cancer ache who have been handled with a medical hashish cultivar. Females have been extra inclined to antagonistic results from hashish than their male counterparts.

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In a 2010 assessment, researchers got here up with the next conclusions on how women and men reply to hashish in a different way.


  • Elevated meals consumption
  • Elevated power homeostasis
  • Decreased sexual habits


  • Elevated analgesia
  • Elevated anxiousness
  • Elevated sexual habits

It’s clear that women and men have key variations within the ECS which have an effect on their response to cannabinoids. Nonetheless, analysis proof on the precise mechanisms is usually preliminary and scanty. Moreover, there’s a paucity of analysis on females, and this cuts throughout completely different fields. Additional research on this space are important to information hashish prescription for medical and leisure use.

This text initially appeared on MyCannabis.com and has been reposted with permission.


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